Selective modulation of interhemispheric connectivity by transcranial alternating current stimulation influences binaural integration

Significance Sensory processing depends upon the integration of widely distributed neural assemblies. During every day listening, our ears receive different information (due to interaural time and amplitude differences) it is known that both hemispheres extract acoustic features. Nonetheless, features belonging same source become integrated. It has been suggested brain overcomes this “binding problem” by synchronization oscillatory activity across relevant regions. Here we probe interhemispheric as a mechanism for feature binding using bihemispheric transcranial alternating current stimulation. Concurrent functional MRI reveals antiphase stimulation auditory areas changes effective connectivity between these areas, change in predicts perceptual dichotic stimuli.